Anti-tumor activity of the crude saponins obtained from asparagus

被引：107
|
作者：
Shao, Y
Chin, CK
Ho, CT
Ma, W
Garrison, SA
Huang, MT
机构：
[1] RUTGERS STATE UNIV,COOK COLL,DEPT FOOD SCI,NEW BRUNSWICK,NJ 08903
[2] RUTGERS STATE UNIV,COOK COLL,DEPT PLANT SCI,NEW BRUNSWICK,NJ 08903
[3] RUTGERS STATE UNIV,DEPT BIOL CHEM,CANC RES LAB,COLL PHARM,PISCATAWAY,NJ 08855
来源：
CANCER LETTERS | 1996年 / 104卷 / 01期
关键词：
asparagus; vegetable; saponin; antitumor; anti-leukemia;
D O I：
10.1016/0304-3835(96)04233-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The crude saponins from the shoots (edible part of asparagus) of asparagus (asparagus crude saponins; ACS) were found to have antitumor activity. The ACS inhibited the growth of human leukemia HL-60 cells in culture and macromolecular synthesis in a dose and time dependent manner. The ACS at 75-100 mu g/ml range was cytostatic. ACS concentrations greater than 200 mu g/ml were cytocidal to HL60 cells. The ACS at 6 and 50 mu g/ml inhibited the synthesis of DNA, RNA and protein in HL-60 cells by 41, 5, and 4, respectively, or by 84, 68 and 59%,respectively. The inhibitory effect of ACS on DNA synthesis was irreversible.
引用
收藏
页码：31 / 36
页数：6
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