1,3,4-Thiadiazoles: A potent multi targeted pharmacological scaffold

被引：151
|
作者：
Haider, Saqlain [1 ,2 ]
Alam, Mohammad Samar [2 ]
Hamid, Hinna [2 ]
机构：
[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
[2] Jamia Hamdard, Fac Sci, Dept Chem, New Delhi 110062, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 92卷
关键词：
1,3,4-Thiadiazole; Mesoionic; Syndones; Anticancer; Anti-inflammatory; Hyperlipidaemia; CARBONIC-ANHYDRASE INHIBITORS; ANTI-HIV ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITIES; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTITUMOR-ACTIVITY; DERIVATIVES; ACETAZOLAMIDE; DESIGN;
D O I：
10.1016/j.ejmech.2014.12.035
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Despite a significant work on thiadiazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent biological activities. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects. This review throws light on the detailed synthetic approaches which have been used for the synthesis of thiadiazoles. This has been followed by the in depth analysis of the thiadiazoles with respect to their medicinal significance. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：156 / 177
页数：22
相关论文
共 50 条
  • [31] 2-(1-PHENOXYETHYL)-1,3,4-THIADIAZOLES AS ACARICIDES
    YAMADA, M
    MATSUMOTO, S
    OHTA, H
    SUZUKI, S
    HIGASHINO, Y
    FUKUCHI, T
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 202 : 71 - AGRO
  • [32] PHOTOCHEMICAL FRAGMENTATION OF MESOTONIC 1,3,4-THIADIAZOLES - MECHANISTIC OBSERVATION
    MUKHERJEE, R
    MORIARTY, RM
    TETRAHEDRON, 1976, 32 (06) : 661 - 664
  • [33] MESO-IONIC 1,3,4-THIADIAZOLES - PHOTOCHEMICAL FRAGMENTATION
    MORIARTY, RM
    MUKHERJE.R
    TETRAHEDRON LETTERS, 1969, (53) : 4627 - &
  • [34] QUATERNIZATION REACTIONS .5. QUATERNIZATION OF 1,3,4-THIADIAZOLES
    LUND, H
    ACTA CHEMICA SCANDINAVICA, 1973, 27 (02): : 391 - 395
  • [35] Solid-phase synthesis of substituted 1,3,4-thiadiazoles
    Kilburn, JP
    Lau, J
    Jones, RCF
    TETRAHEDRON LETTERS, 2003, 44 (42) : 7825 - 7828
  • [36] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 5-SUBSTITUTED 2-(N,N-DIALKYLAMINOETHYL)AMINO-1,3,4-THIADIAZOLES AND 2-N-METHYLPIPERAZINYL-1,3,4-THIADIAZOLES
    LALEZARI, I
    SHAFIEE, A
    BADALY, A
    SALIMI, MM
    KHOYI, MA
    ABTAHI, F
    ZARRINDAST, MR
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (07) : 1250 - 1252
  • [37] MICROWAVE SPECTRA OF ISOTOPIC 1,3,4-THIADIAZOLES . MOLECULAR STRUCTURE OF 1,3,4-THIADIAZOLE
    BAK, B
    NYGAARD, L
    PEDERSEN, EJ
    RASTRUPA.J
    JOURNAL OF MOLECULAR SPECTROSCOPY, 1966, 19 (03) : 283 - &
  • [38] SUBSTITUTED 1,3,4-THIADIAZOLES WITH ANTICONVULSANT ACTIVITY .1. HYDRAZINES
    CHAPLEO, CB
    MYERS, M
    MYERS, PL
    SAVILLE, JF
    SMITH, ACB
    STILLINGS, MR
    TULLOCH, IF
    WALTER, DS
    WELBOURN, AP
    JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) : 2273 - 2280
  • [39] PREPARATION OF 2-ALKYLAMINO-1,3,4-THIADIAZOLES
    COBURN, RA
    BHOOSHAN, B
    GLENNON, RA
    JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (22): : 3947 - 3949
  • [40] Pyranoquinolone derivatives: A potent multi-targeted pharmacological scaffold
    Uppal, Jasreen
    Mir, Prince Ahad
    Chawla, Apporva
    Kumar, Nishant
    Kaur, Gurinder
    Bedi, Preet Mohinder Singh
    Bhandari, Divya Dhawal
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2023, 60 (03) : 369 - 391
12345