SNS-595 causes selective double strand breaks during S-phase which are solely repaired through non-homologous end joining

被引:0
|
作者
Hyde, Jennifer [1 ]
Wright, Jasmin [1 ]
Walker, Duncan H. [1 ]
Silverman, Jeffrey A. [1 ]
Arkin, Michelle R. [1 ]
机构
[1] Sunesis Pharmaceut, San Francisco, CA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2074
引用
收藏
页数:1
相关论文
共 50 条
  • [31] In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density
    N. T. Henthorn
    J. W. Warmenhoven
    M. Sotiropoulos
    R. I. Mackay
    N. F. Kirkby
    K. J. Kirkby
    M. J. Merchant
    Scientific Reports, 8
  • [32] Structural mechanism of DNA-end synapsis in the non-homologous end joining pathway for repairing double-strand breaks: bridge over troubled ends
    Wu, Qian
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2019, 47 : 1609 - 1619
  • [33] Synergistic Roles of Non-Homologous End Joining and Homologous Recombination in Repair of Ionizing Radiation-Induced DNA Double Strand Breaks in Mouse Embryonic Stem Cells
    van de Kamp, Gerarda
    Heemskerk, Tim
    Kanaar, Roland
    Essers, Jeroen
    CELLS, 2024, 13 (17)
  • [34] Analysis of chromatid-break-repair detects a homologous recombination to non-homologous end-joining switch with increasing load of DNA double-strand breaks
    Murmann-Konda, Tamara
    Soni, Aashish
    Stuschke, Martin
    Iliakis, George
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2021, 867
  • [35] CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
    Quennet, Verena
    Beucher, Andrea
    Barton, Olivia
    Takeda, Shunichi
    Loebrich, Markus
    NUCLEIC ACIDS RESEARCH, 2011, 39 (06) : 2144 - 2152
  • [36] Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
    Noh, Sung-Eun
    Juhnn, Yong-Sung
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [37] ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
    Lee, Kyung Yong
    Im, Jun-Sub
    Shibata, Etsuko
    Dutta, Anindya
    MOLECULAR CELL, 2017, 68 (01) : 61 - +
  • [38] The requirement of a Ku-IP6 (inositol hexakisphosphate) complex for efficient repair of DNA double strand breaks by non-homologous end joining in mammals
    Cheung, Joyce C. Y.
    Hanakahi, Les A.
    FASEB JOURNAL, 2007, 21 (05): : A292 - A292
  • [39] Post-cleavage target residence determines asymmetry in non-homologous end joining of Cas12a-induced DNA double strand breaks
    Ruo-Dan Chen
    Yi Yang
    Kun-Ming Liu
    Jing-Zhen Hu
    Yi-Li Feng
    Chun-Yi Yang
    Rui-Rui Jiang
    Si-Cheng Liu
    Yue Wang
    Ping-An Han
    Ru-Gang Tian
    Yu-Long Wang
    Shi-Ming Xu
    An-Yong Xie
    Genome Biology, 26 (1)
  • [40] Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
    Sung-Eun Noh
    Yong-Sung Juhnn
    Scientific Reports, 10