An efficient palladium catalyzed synthesis of 2-arylbenzothiazoles

被引：73
|
作者：
Majo, VJ [1 ]
Prabhakaran, J [1 ]
Mann, JJ [1 ]
Kumar, JSD [1 ]
机构：
[1] Columbia Univ, Dept Psychiat & Neurosci, NYSPI, New York, NY 10032 USA
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 47期
关键词：
boronic acid; benzothiazole; Suzuki coupling; palladium;
D O I：
10.1016/j.tetlet.2003.09.138
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and convergent palladium catalyzed synthesis of 2-arylbenzothiazoles has been investigated. The key step in the synthesis is a Suzuki biaryl coupling of 2-bromobenzothiazole with aryl boronic acids to provide a variety of 2-arylbenzothiazole derivatives in good yield. The synthetic utility of this methodology is demonstrated by the synthesis of 2-(4-aminophenyl)-6-methoxybenzothiazole, a PET probe precursor for the in vivo imaging of Alzheimer's disease. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8535 / 8537
页数：3
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