Association of the 5-HT2A receptor gene promoter polymorphism-1438G/A with anorexia nervosa and psychopathological traits in the Chinese Han population: A preliminary study

被引：6
|
作者：
Kang, Qing [1 ]
Chen, Jue [1 ]
Yu, Shunying [1 ]
Yuan, Aihua [1 ]
Zhang, Yanxia [1 ]
Zhang, Ran [1 ]
Jiang, Wenhui [1 ]
Zhang, Chen [1 ]
Zhang, Haiyin [1 ]
Zhang, Mingdao [1 ]
Xiao, Zeping [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China
来源：
ASIA-PACIFIC PSYCHIATRY | 2017年 / 9卷 / 03期
基金：
中国国家自然科学基金;
关键词：
-1438G; A; 5-HT2A receptor gene promoter polymorphism; anorexia nervosa; Chinese Han; psychopathological traits of eating-disordered behavior; EATING-DISORDERS; JAPANESE PATIENTS; BULIMIA-NERVOSA; SUSCEPTIBILITY;
D O I：
10.1111/appy.12284
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
ObjectiveThe aim of the study was to explore the possible role of the 5-HT2A-1438G/A polymorphism in the susceptibility to anorexia nervosa (AN) in the Chinese Han population. MethodsThe -1438G/A polymorphism of 249 female AN patients, 228 matched healthy controls, and 198 trios was genotyped using SNaP shot assay. Psychopathological traits of eating-disordered behaviors in AN subjects were examined using the Chinese version of the Eating Disorder Examination Questionnaire. ResultsNeither the case-control analysis nor the transmission disequilibrium test revealed significant associations between the -1438G/A polymorphism and AN (P>.05). However, AA homozygote patients with AN had lower weight and shape concern scores of the EDE-Q6.0 than those of GA heterozygotes (P<.05). DiscussionOur findings suggested that female AN patients with 5-HT2A -1438AA genotype may be characterized by less severe eating-disordered psychopathological traits in the Chinese Han population.
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页数：4
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