Association of the 5-HT2A receptor gene promoter polymorphism-1438G/A with anorexia nervosa and psychopathological traits in the Chinese Han population: A preliminary study

被引：6

作者：

Kang, Qing ^{[1
]}

Chen, Jue ^{[1
]}

Yu, Shunying ^{[1
]}

Yuan, Aihua ^{[1
]}

Zhang, Yanxia ^{[1
]}

Zhang, Ran ^{[1
]}

Jiang, Wenhui ^{[1
]}

Zhang, Chen ^{[1
]}

Zhang, Haiyin ^{[1
]}

Zhang, Mingdao ^{[1
]}

Xiao, Zeping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China

来源：

ASIA-PACIFIC PSYCHIATRY | 2017年 / 9卷 / 03期

基金：

中国国家自然科学基金;

关键词：

-1438G; A; 5-HT2A receptor gene promoter polymorphism; anorexia nervosa; Chinese Han; psychopathological traits of eating-disordered behavior; EATING-DISORDERS; JAPANESE PATIENTS; BULIMIA-NERVOSA; SUSCEPTIBILITY;

D O I：

10.1111/appy.12284

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

ObjectiveThe aim of the study was to explore the possible role of the 5-HT2A-1438G/A polymorphism in the susceptibility to anorexia nervosa (AN) in the Chinese Han population. MethodsThe -1438G/A polymorphism of 249 female AN patients, 228 matched healthy controls, and 198 trios was genotyped using SNaP shot assay. Psychopathological traits of eating-disordered behaviors in AN subjects were examined using the Chinese version of the Eating Disorder Examination Questionnaire. ResultsNeither the case-control analysis nor the transmission disequilibrium test revealed significant associations between the -1438G/A polymorphism and AN (P>.05). However, AA homozygote patients with AN had lower weight and shape concern scores of the EDE-Q6.0 than those of GA heterozygotes (P<.05). DiscussionOur findings suggested that female AN patients with 5-HT2A -1438AA genotype may be characterized by less severe eating-disordered psychopathological traits in the Chinese Han population.

引用

页数：4

共 50 条

[1] Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa
Ricca, V
Nacmias, B
Boldrini, M
Cellini, E
di Bernardo, M
Ravaldi, C
Tedde, A
Bagnoli, S
Placidi, GF
Rotella, CM
Sorbi, S
NEUROSCIENCE LETTERS, 2004, 365 (02) : 92 - 96
[2] 5-HT2A promoter polymorphism-1438G/A, anorexia nervosa, and obsessive-compulsive disorder
Enoch, MA
Kaye, WH
Rotondo, A
Greenberg, BD
Murphy, DL
Goldman, D
LANCET, 1998, 351 (9118): : 1785 - 1786
[3] Association between 5-HT2A gene promoter polymorphism and anorexia nervosa
Collier, DA
Arranz, MJ
Li, T
Mupita, D
Brown, N
Treasure, J
LANCET, 1997, 350 (9075): : 412 - 412
[4] 5-HT2A gene promoter polymorphism and anorexia nervosa
Ziegler, A
Görg, T
LANCET, 1999, 353 (9156): : 929 - 929
[5] 5-HT2A gene promoter polymorphism in anorexia nervosa.
Kipman, A
Gorwood, P
Bruins-Slot, S
Hanoun, N
Adès, J
Boni, C
Hamon, M
Mouren-Siméoni, MC
AMERICAN JOURNAL OF MEDICAL GENETICS, 2000, 96 (04): : 502 - 502
[6] 5-HT2A promoter polymorphism in anorexia nervosa
Sorbi, S
Nacmias, B
Tedde, A
Ricca, V
Mezzani, B
Rotella, CM
LANCET, 1998, 351 (9118): : 1785 - 1785
[7] No association, between 5-HT2A receptor promoter gene polymorphism,1438A/G and homicide in schizophrenics
Chee, IS
Lee, SW
Lee, YH
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2002, 12 : S299 - S299
[8] Association of the promoter polymorphism - 1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa
Bruce, KR
Steiger, H
Joober, R
Kin, NMKNY
Israel, M
Young, SN
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 137B (01) : 40 - 44
[9] 5-HT2A receptor gene promoter polymorphism -: 1438G/A and mood disorders
Ohara, K
Nagai, M
Tsukamoto, T
Tani, K
Suzuki, Y
Ohara, K
NEUROREPORT, 1998, 9 (06) : 1139 - 1141
[10] Lack of association between 5-HT2A gene promoter polymorphism and susceptibility to anorexia nervosa
Campbell, DA
Sundaramurthy, D
Markham, AF
Pieri, LF
LANCET, 1998, 351 (9101): : 499 - 499

← 1 2 3 4 5 →