Investigating the Survival Benefit of Combining Radiotherapy for Surgery Treated Locally Advanced Esophageal Squamous Cell Carcinoma Patients Aged 65 and Older

被引:2
|
作者
Huang, Shan [1 ]
Li, Yuxing [1 ]
Ma, Hongbing [1 ]
Wang, Wenyu [2 ]
Zheng, Shuyu [2 ]
Ke, Yue [1 ]
Li, Fang [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Radiat Oncol, 157 Xi Wu Rd, Xian 710004, Shaanxi, Peoples R China
[2] Univ Helsinki, Helsinki Inst Life Sci, Inst Mol Med Finland FIMM, Helsinki 00014, Finland
关键词
Esophageal squamous cell carcinoma; Aged 65 and older; Surgery; Radiotherapy; Survival; CHEMORADIOTHERAPY; CANCER;
D O I
10.1007/s11605-019-04200-5
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
PurposeTo evaluate the survival benefit of combining radiotherapy with surgery in locally advanced esophageal squamous cell carcinoma (ESCC) patients aged over 65.MethodsUsing the SEER database, we selected patients age >= 65 years that were diagnosed as locally advanced ESCC during 2004-2013. Cancer-specific survival (CSS) was examined using the Kaplan-Meier analysis and compared by the log-rank test. Univariable and multivariable Cox proportional hazard models were established to identify possible prognostic factors.ResultsA total of 972 cases were included in the study. For surgical patients aged 65-79 years, 74 patients (32.9%) were treated by surgery alone and 122 patients (54.2%) had received additional neoadjuvant radiotherapy (NRT). NRT+surgery was associated with improved CSS comparing with surgery alone (HR, 0.58; 95%CI, 0.39 to 0.85; P=0.005). In subgroup analysis, NRT was associated with improved CSS for patients aged 65-74 years (2-year CSS 56.6% versus 39.6%, P=0.026). No significant differences of progonosis was observed for different treatment groups in 75-79 years patients (P=0.972).ConclusionsIn this SEER-based study, the addition of neoadjuvant radiotherapy before surgery was associated with improved CSS for locally advanced ESCC patients aged 65 to 74 years.
引用
收藏
页码:2111 / 2118
页数:8
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