Fluctuations in anti-Mullerian hormone levels throughout the menstrual cycle parallel fluctuations in the antral follicle count: a cohort study

被引：21

作者：

Depmann, Martine ^{[1
]}

Van Disseldorp, Jeroen ^{[1
]}

Broer, Simone L. ^{[1
]}

Eijkemans, Marinus J. C. ^{[2
]}

Laven, Joop S. E. ^{[3
]}

Visser, Jenny A. ^{[4
]}

De Rijke, Yolanda B. ^{[4
,5
]}

Mol, Ben W. ^{[6
]}

Broekmans, Frank J. M. ^{[1
]}

机构：

[1] Univ Med Ctr, Dept Reprod Med & Gynecol, Utrecht, Netherlands

[2] Julius Ctr Hlth Sci & Primary Care, Dept Biostat & Res Support, Utrecht, Netherlands

[3] Erasmus MC, Dept Obstet & Gynecol, Rotterdam, Netherlands

[4] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[5] Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands

[6] Univ Adelaide, Robinson Res Inst, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia

来源：

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 2016年 / 95卷 / 07期

关键词：

Anti-Mullerian hormone; antral follicle count; fluctuation; ANTIMULLERIAN HORMONE; INHIBIN-B; AGE; MENOPAUSE; WOMEN; PREDICTOR; TIME; ULTRASONOGRAPHY; ESTRADIOL; OBESITY;

D O I：

10.1111/aogs.12886

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Introduction. In this prospective cohort study we aimed to investigate the hypothesis that fluctuations in anti-Mullerian hormone levels stem from fluctuations in the number of antral follicles. Material and methods. Repeated measurements of anti-Mullerian hormone and antral follicles (follicles 2-8 mm) were performed in 44 women with a regular cycle, during one menstrual cycle. If our hypothesis that anti-Mullerian hormone fluctuations stem from fluctuations in the antral follicles is correct, a fluctuation in the antral follicles would result in an equal and parallel shift in anti-Mullerian hormone. Hence, the difference between antral follicles and anti-Mullerian hormone would remain constant over time. A mixed model analysis, assessing the stability between anti-Mullerian hormone and antral follicles, was performed using the difference between (log)antral follicles and (log)anti-Mullerian hormone. Cohen's D was calculated for the largest of fixed effects in order to assess stability in relative distance between antral follicles and anti-Mullerian hormone. To assess if fluctuation in anti-Mullerian hormone or antral follicles originated from between-subject fluctuation, or from within subject fluctuation, the intra-class correlation coefficient was calculated. Results. Mixed model analysis and Cohen's D (0.12) confirmed the stability of the difference between (log)antral follicles and (log)anti-Mullerian hormone and so confirmed our hypothesis. The good intra-class correlation coefficient (0.73) indicated a small contribution of within-subject variation to anti-Mullerian hormone fluctuations. Conclusions. Fluctuations in anti-Mullerian hormone levels parallel fluctuations in antral follicles, suggesting that anti-Mullerian hormone levels are closely linked to variation in the antral follicles. This knowledge adds to the basic understanding of the origin of anti-Mullerian hormone and could aid in interpretation of individual anti-Mullerian hormone levels.

引用

页码：820 / 828

页数：9

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