Biomarkers of laryngeal squamous cell carcinoma: a review

被引：34

作者：

Cavaliere, Matteo ^{[1
]}

Bisogno, Antonella ^{[1
]}

Scarpa, Alfonso ^{[1
]}

D'Urso, Alessia ^{[1
]}

Marra, Pasquale ^{[1
]}

Colacurcio, Vito ^{[1
]}

De Luca, Pietro ^{[1
]}

Ralli, Massimo ^{[2
]}

Cassandro, Ettore ^{[1
]}

Cassandro, Claudia ^{[3
]}

机构：

[1] Univ Salerno, Dept Med & Surg, Via Salvador Allende 43, I-84081 Salerno, Italy

[2] Sapienza Univ Rome, Dept Sense Organs, Viale Policlin 155, I-00161 Rome, Italy

[3] Univ Turin, Surg Sci Dept, Corso Dogliotti 14, I-10124 Turin, Italy

来源：

ANNALS OF DIAGNOSTIC PATHOLOGY | 2021年 / 54卷

关键词：

Laryngeal neoplasms; RNA; long noncoding; Ki-67; antigen; Focal adhesion protein-tyrosine kinases; Cyclin D1; Tumour suppressor protein p53; Cadherins; Receptors; growth factor; E-CADHERIN EXPRESSION; FOCAL-ADHESION KINASE; PREDICTS RADIOTHERAPY FAILURE; FACTOR RECEPTOR EXPRESSION; KI-67; ANTIGEN-EXPRESSION; LYMPH-NODE METASTASES; PROGNOSTIC-SIGNIFICANCE; GROWTH-FACTOR; HUMAN-PAPILLOMAVIRUS; BCL-2; EXPRESSION;

D O I：

10.1016/j.anndiagpath.2021.151787

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Laryngeal carcinoma is the second common malignancy of the upper aerodigestive tract after lung cancer; in most cases is a squamous cell carcinoma, whose risk factors include tobacco smoking and alcohol consumption. Despite therapeutic progress, the five-year overall survival rate for this malignancy has remained nearly 50% and many patients already present metastasis at the time of diagnosis. To date, there are no tools that predict the evolution of laryngeal carcinoma: in this light, during the last years, many studies were planned with the aim to investigate the role played by different biomarkers expressed by larynx cancer, which can help make an early diagnosis, predict disease evolution and direct therapeutic choice. This review aims to summarize these markers and correlating them with disease evolution.

引用

页数：10

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