The Qiashikansayi granodiorite is foliated resulting in a granodioritic gneiss. Its geochemical features, such as alumina saturation index(A/CNK) of 0.81-0.99, Na2O/K2O values > 1, TiO2 contents < 1.0%, LREE enrichment with high fractionation factors, weakly negative or no Eu anomalies, and significant Ba and Ti negative anomalies, suggest that it is similar to a typical island arc pluton. The trace elements of the Qiashikansayi granodiorite are plotted in the island arc field in the tectonic setting discrimination diagrams as well. Cathodoluminescence images demonstrated that the zircons have clear rhythmic crystallized zoning, without any remnant core and new crystallized rim, suggesting the zircons be magmatic ones. Their U and Th contents vary in the range of 574-870 mu g/g, and 279-556 mu g/g respectively, with the Th/U ratio in the range of 0.52-0.68. SHRIMP zircon U-Pb dating yielded the 481.5 +/- 5.3 Ma age for the intrusion of the granodiorite, which is coeval with the island are volcanic rocks in the northern Qilian Mountain, and confirms that there is an early Paleozoic island arc in the Hongliugou- Lapeiquan area.