Copper-catalyzed tandem phosphination-decarboxylation-oxidation of alkynyl acids with H-phosphine oxides: a facile synthesis of β-ketophosphine oxides

被引：93
|
作者：
Zhang, Pengbo [1 ,2 ]
Zhang, Liangliang [1 ,2 ]
Gao, Yuzhen [1 ,2 ]
Xu, Jian [1 ,2 ]
Fang, Hua [3 ]
Tang, Guo [1 ,2 ]
Zhao, Yufen [1 ,2 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China
[2] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China
[3] State Ocean Adm, Inst Oceanog 3, Xiamen 361005, Fujian, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 37期
关键词：
C-P; DIRECT OXYPHOSPHORYLATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; PHOSPHONATES; HOST; BLUE; ALKYNYLPHOSPHONATES; HYDRATION; STRATEGY;
D O I：
10.1039/c5cc01904d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The general method for the tandem phosphination-decarboxylation-oxidation of alkynyl acids under aerobic conditions has been developed. In the presence of CuSO4 center dot 5H(2)O and TBHP, the reactions provide a novel access to beta-ketophosphine oxides in good to excellent yields. This transformation allows the direct formation of a P-C bond and the construction of a keto group in one reaction.
引用
收藏
页码：7839 / 7842
页数：4
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