Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing

被引:23
|
作者
Zhao, Min [1 ,2 ]
Rolandi, Marco [3 ]
Isseroff, R. Rivkah [2 ]
机构
[1] Univ Calif Davis, Dept Ophthalmol & Vis Sci, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Dept Dermatol, Davis, CA 95616 USA
[3] Univ Calif Santa Cruz, Dept Elect & Comp Engn, Santa Cruz, CA 95064 USA
来源
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2022年 / 14卷 / 10期
基金
美国国家卫生研究院;
关键词
EPIDERMAL CALCIUM GRADIENT; EPITHELIAL SODIUM-CHANNEL; PHYSIOLOGICAL ELECTRIC-FIELDS; SKIN BARRIER FUNCTION; IN-VITRO; HUMAN KERATINOCYTES; TIGHT JUNCTIONS; DIRECTED MIGRATION; DORSAL CLOSURE; E-CADHERIN;
D O I
10.1101/cshperspect.a041236
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In wound healing, individual cells' behaviors coordinate movement toward the wound center to restore small or large barrier defects. The migration of epithelial cells as a continuous sheet structure is one of the most important processes by which the skin barrier is restored. How such multicellular and tissue level movement is initiated upon injury, coordinated during healing, and stopped when wounds healed has been a research focus for decades. When skin is wounded, the compromised epithelial barrier generates endogenous electric fields (EFs), produced by ion channels and maintained by cell junctions. These EFs are present across wounds, with the cathodal pole at the wound center. Epithelial cells detect minute EFs and migrate directionally in response to electrical signals. It has long been postulated that the naturally occurring EFs facilitate wound healing by guiding cell migration. It is not until recently that experimental evidence has shown that large epithelial sheets of keratinocytes or corneal epithelial cells respond to applied EFs by collective directional migration. Although some of the mechanisms of the collective cell migration are similar to those used by isolated cells, there are unique mechanisms that govern the coordinated movement of the cohesive sheet. We will review the understanding of wound EFs and how epithelial cells and other cells important to wound healing respond to the electric signals individually as well as collectively. Mounting evidence suggests that wound bioelectrical signaling is an important mechanism in healing. Critical understanding and proper exploitation of this mechanism will be important for better wound healing and regeneration.
引用
收藏
页数:24
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