Small-molecule inhibitors of cell signaling

被引：25
|
作者：
McCormick, F [1 ]
机构：
[1] Canc Res Inst, San Francisco, CA 94115 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 06期
关键词：
D O I：
10.1016/S0958-1669(00)00149-X
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Small-molecule inhibitors of several intracellular signaling proteins, mostly protein kinases, show tremendous selectivity and potency. The complexity and redundancy of signaling pathways presents opportunities for therapeutic selectivity and some clinical results are remarkable. New strategies are being developed to interfere with previously intractable targets, such as protein-protein interactions.
引用
收藏
页码：593 / 597
页数：5
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