Acute kidney injury in hospitalized COVID-19 patients

被引:12
|
作者
Kanbay, Mehmet [1 ]
Medetalibeyoglu, Alpay [2 ]
Kanbay, Asiye [3 ]
Cevik, Enes [4 ]
Tanriover, Cem [4 ]
Baygul, Arzu [5 ,6 ]
Senkal, Naci [2 ]
Konyaoglu, Hilal [2 ]
Akpinar, Timur S. [2 ]
Kose, Murat [2 ]
Covic, Adrian [7 ]
Tukek, Tufan [2 ]
机构
[1] Koc Univ, Sch Med, Dept Med, Div Nephrol, TR-34010 Istanbul, Turkey
[2] Istanbul Univ, Sch Med, Dept Med, Istanbul, Turkey
[3] Atasehir Medicana Hosp, Dept Pulm Med, Istanbul, Turkey
[4] Koc Univ, Sch Med, Dept Med, Istanbul, Turkey
[5] Koc Univ, Sch Med, Dept Biostat, Istanbul, Turkey
[6] Koc Univ, Res Ctr Translat Med KUTTAM, Istanbul, Turkey
[7] Grigore T Popa Univ Med, Dept Nephrol, Iasi, Romania
关键词
COVID-19; Acute kidney injury; Hospital stay; Mortality; CORONAVIRUS; INFECTION; DISEASE; FEATURES;
D O I
10.1007/s11255-021-02972-x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in hospitalized patients are not well studied. Materials and methods This is a retrospective cohort study conducted in two major university hospitals. Electronic health records of the patients, 18 years or older, hospitalized between 13 April and 1 June 2020 with confirmed COVID-19 were reviewed. We described the incidence and the risk factors for AKI development in COVID-19 patients. Furthermore, we investigated the effects of AKI on the length of hospital and intensive care unit (ICU) stay, the admission rates to ICU, the percentage of patients with cytokine storm and in-hospital mortality rate. Results Among 770 hospitalized patients included in this study, 92 (11.9%) patients developed AKI. The length of hospitalized days (16 vs 9.9, p < 0.001) and days spent in the hospital until ICU admission (3.5 vs. 2.5, p = 0.003) were higher in the AKI group compared to patients without AKI. In addition, ICU admission rates were also significantly higher in patients with AKI (63% vs. 20.7%, p < 0.001). The percentage of patients with AKI who developed cytokine storm was significantly higher than patients without AKI (25.9% vs. 14%, p = 0.009). Furthermore, the in-hospital mortality rate was significantly higher in patients with AKI (47.2% vs. 4.7%, p < 0.001). Conclusions AKI is common in hospitalized COVID-19 patients. Furthermore, we show that AKI increases the admission rates to ICU and in-hospital mortality. Our findings suggest that AKI should be effectively managed to prevent the adverse outcomes in COVID-19 patients.
引用
收藏
页码:1097 / 1104
页数:8
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