Acceleration of Umbilical Cord Blood (UCB) Stem Engraftment: Results of a Phase I Clinical Trial with Stemregenin-1 (SR1) Expansion Culture

被引：5
|
作者：
Wagner, John E. [1 ]
Brunstein, Claudio [2 ]
McKenna, David [3 ]
Sumstad, Darin [4 ]
Maahs, Suzanne [5 ]
Laughlin, Mary J. [6 ]
Perry, Michael S. [7 ]
Boitano, Anthony E. [8 ]
Cooke, Michael [8 ]
Bleul, Conrad C. [9 ]
机构：
[1] Univ Minnesota, Minneapolis, MN USA
[2] Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA
[3] Univ Minnesota, St Paul, MN 55108 USA
[4] Univ Minnesota, Med Ctr, St Paul, MN 55108 USA
[5] Novartis Inst BioMed Res, E Hanover, NJ USA
[6] Novartis Pharmaceut, Stem Cell Therapy Integrat Hosp Care Franchise, E Hanover, NJ USA
[7] Novartis Pharmaceut, E Hanover, NJ USA
[8] Novartis Res Fdn, Genom Inst, San Diego, CA USA
[9] Translat Med ATI, Novartis Inst Biomed Res, Basel, Switzerland
来源：
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2015年 / 21卷 / 02期
关键词：
D O I：
10.1016/j.bbmt.2014.11.043
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
29
引用
收藏
页码：S48 / S49
页数：2
相关论文
共 30 条
  • [21] Low Dose IGFBP1, IGFBP2 and ANGPTL3 Coordinately Stimulate Ex Vivo Expansion of Human Umbilical Cord Blood (UCB) Hematopoietic Stem Cells (HSCs)
    Fan, Xiubo
    Chu, Pak Yan
    Gay, Florence
    Bari, Sudipto
    Ang, Justina
    Lim, SaiKiang
    Hwang, William
    BLOOD, 2010, 116 (21) : 657 - 657
  • [22] Treatment of Optic Canal Decompression Combined with Umbilical Cord Mesenchymal Stem (Stromal) Cells for Indirect Traumatic Optic Neuropathy: A Phase 1 Clinical Trial
    Li, Jia
    Bai, Xu
    Guan, Xiaoyue
    Yuan, Hongfeng
    Xu, Xiang
    OPHTHALMIC RESEARCH, 2021, 64 (03) : 398 - 404
  • [23] Phase 1/2 randomized clinical trial of intravenous infusion of umbilical cord mesenchymal stem cells in patients with chronic cardiopathy with stable heart failure (RIMECARD)
    Bartolucci, J.
    Verdugo, F. J.
    Larrea, R.
    Abarzua, E.
    Goset, C.
    Rojo, P.
    Palma, I.
    Gonzalez, P. L.
    Sanhueza, P.
    Pedreros, P.
    Lamich, R.
    Valdivia, G.
    Nazzal, C.
    Khoury, M.
    Figueroa, F. E.
    EUROPEAN HEART JOURNAL, 2016, 37 : 527 - 527
  • [24] TREAT-ME 1: Treatment of advanced gastrointestinal cancer in a clinical phase I/II trial with genetically modified mesenchymal stem cells: Clinical results of a phase I study
    von Einem, Jobst C.
    Niess, Hanno
    Michl, Marlies
    Nelson, Peter J.
    Scherhammer, Volker
    Guenther, Christine
    Salat, Christoph
    Stoetzer, Oliver J.
    Angele, Martin K.
    Bruns, Christiane J.
    Heinemann, Volker
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [25] Human umbilical cord-derived mesenchymal stem cells for the treatment of decompensated cirrhosis (MSC-DLC-1): a dose-escalation, phase I trial protocol
    Wang, Zerui
    Li, Tiantian
    Zhang, Ziying
    Yuan, Mengqi
    Shi, Ming
    Wang, Fu-Sheng
    Linghu, En-Qiang
    Shi, Lei
    BMJ OPEN, 2023, 13 (12):
  • [26] Results of phase 1 clinical trial evaluating efficacy of 3rd party cord blood regulatory T cells for prevention of graft versus host disease
    Kellner, Joshua
    Yvon, Eric
    Khoury, Joseph
    Tuongvan Nguyen
    Ramos, Jennifer
    Olson, Amanda Leigh
    Nieto, Yago
    Ciurea, Stefan O.
    Nierkens, Stefan
    Delemarre, Elena
    Boelens, Jaap Jan
    Champlin, Richard E.
    Andersson, Borje
    Parmar, Simrit
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [27] Repeated intravenous doses of human umbilical cord-derived mesenchymal stromal cells for bronchopulmonary dysplasia: results of a phase 1 clinical trial with 2-year follow-up
    Marin, Maria Jesus del Cerro
    Ormazabal, Itziar Garcia
    Gimeno-Navarro, Ana
    Alvarez-Fuente, Maria
    Lopez-Ortego, Paloma
    Avila-Alvarez, Alejandro
    Arruza Gomez, Luis
    Gonzalez-Menchen, Cristina
    de Lera, Carlos Labrandero
    Balseiro, Maria Lozano
    Gutierrez, Laura Moreno
    Frajilich, Gustavo Melen
    Orellana, Manuel Ramirez
    Garcia, Natalia Saldan
    Delgado, Antonio Pavon
    Torres, Maximo Vento
    CYTOTHERAPY, 2024, 26 (06) : 632 - 640
  • [28] Long-term Safety of a Single Infusion of Human Umbilical Cord Blood-derived Mesenchymal Stem Cell Therapy in Rheumatoid Arthritis: The 5-year Follow-up of the Phase I Clinical Trial
    Kim, Min Jung
    Park, Eun Hye
    Shin, Kichul
    ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 3566 - 3567
  • [29] CLINICAL OUTCOMES IN PEPTIDE C PRODUCTION IN TYPE 1 DIABETES PATIENTS TREATED WITH ENDOVASCULAR PANCREATIC INFUSION OF AUTOLOGOUS EXPANDED BONE MARROW MESENCHYMAL STEM CELLS AX(BM-MSC). RESULTS FROM PHASE I CLINICAL TRIAL
    Arturo, J.
    Lucena, C.
    Perez, C.
    Castro, P. J.
    Gonzalez, E.
    Bastidas, Y.
    Vivas, L.
    Ruiz, C.
    Segura, O.
    Esteban, C.
    Lucena, E.
    Lenis, S.
    Dager, A.
    CYTOTHERAPY, 2018, 20 (05) : S115 - S115
  • [30] First in Human RESKUE Phase 1/2 Clinical Trial of Intravenous FBX-101 (AAVrh10. hGALC) Administered after Immune and Myeloablation for Unrelated Umbilical Cord Blood Transplantation Prevented Immune Responses, Increased GALC Activity, Restored Normal Brain Development, and Normalized Motor Function in Patients with Infantile Krabbe Disease
    Escolar, Maria L.
    Vander Lugt, Mark
    Poe, Michele D.
    Greco, Melissa
    Werling, Keith
    De Silva, Erandi K.
    Ruiz, Juan
    Szabolcs, Paul
    MOLECULAR THERAPY, 2023, 31 (04) : 193 - 194
123