VISUAL FUNCTION MEASURES IN EARLY AND INTERMEDIATE AGE-RELATED MACULAR DEGENERATION

被引:59
|
作者
Chandramohan, Arthika [1 ]
Stinnett, Sandra S. [1 ]
Petrowski, John T. [1 ]
Schuman, Stefanie G. [1 ]
Toth, Cynthia A. [1 ]
Cousins, Scott W. [1 ]
Lad, Eleonora M. [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Ophthalmol, DUMC 3802, Durham, NC 27710 USA
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2016年 / 36卷 / 05期
关键词
age-related macular degeneration; visual function testing; low vision; microperimetry; low light visual acuity; low light deficit; contrast sensitivity; TEST-RETEST VARIABILITY; BEAVER-DAM EYE; GEOGRAPHIC ATROPHY; LOW-LUMINANCE; CONTRAST SENSITIVITY; COMPUTERIZED METHOD; TESTING PROTOCOL; DARK-ADAPTATION; COLOR-VISION; ACUITY LOSS;
D O I
10.1097/IAE.0000000000001002
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: The objectives of this study were to evaluate 1) the feasibility of performing computerized tests of low luminance visual acuity (LLVA), cone-specific contrast (Cone Contrast Test [CCT]), contrast sensitivity, and microperimetry and 2) the test-retest repeatability of these outcomes in dry age-related macular degeneration (AMD). Methods: This prospective study enrolled 30 subjects at a single site (8 controls, 8 early AMD, and 12 intermediate AMD). Subjects underwent LLVA, contrast sensitivity, CCT, and microperimetry with eye tracking. Low luminance deficit was defined as best-corrected visual acuity minus LLVA in EDTRS letters. Follow-up testing was administered at approximately 1 month. Results: There was high test-retest repeatability at one month for all visual function metrics (intraclass correlations >0.7) except log contrast sensitivity (intraclass correlations 0.6). Compared with controls, patients with intermediate AMD showed significant deficits on best-corrected visual acuity, LLVA, low luminance deficit, percent-reduced threshold on microperimetry, and red CCT (P < 0.05), but not on contrast sensitivity, green and blue CCT. Conclusion: This pilot study supports the feasibility and reliability of using LLVA, microperimetry, and CCT in early dry AMD. Our data suggest these measures can be used as alternative future clinical trial endpoints. A larger, prospective natural history study of alternative visual function measures in dry AMD is warranted.
引用
收藏
页码:1021 / 1031
页数:11
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