Mitochondrial uncoupling proteins (UCPs) and obesity

被引:0
|
作者
Crowley, V
Vidal-Puig, AJ
机构
[1] Univ Cambridge, Dept Med, Cambridge CB2 2QQ, England
[2] Univ Cambridge, Dept Clin Biochem, Cambridge CB2 2QQ, England
关键词
obesity; brown adipose tissue; thermogenesis; UCP1; homologues; mouse genetic models;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity is now regarded as major public health problem worldwide. Research into this condition has been increasingly focussed on elucidating the cellular and molecular mechanisms regulating mammalian energy intake and expenditure. It is widely acknowledge that the brown adipose tissue (BAT) mitochondrial uncoupling protein (UCP1) plays a pivotal role in adaptive thermogenic responses. Two homologues of UCP1 (UCP2 and UCP3) have recently been identified and population-based genetic studies have linked them with basal metabolic rate while in vitro studies report that both have proton transport activity and may thus be involved in regulation of energy homeostasis and hence obesity. However, evidence from genetically modified animal models indicates that UCP2 and UCP3 have no specific physiological thermogenic function in vivo, though they may still be useful therapeutic targets for obesity. Furthermore, their role in modulating levels of reactive oxygen species and glucose homeostasis is also being investigated.
引用
收藏
页码:70 / 75
页数:6
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