MATRIX INDEPENDENT LABEL-FREE NANOELECTRONIC BIOSENSOR

被引：0

作者：

Esfandyarpour, Rahim ^{[1
,2
]}

Javanmard, Mehdi ^{[2
]}

Koochak, Zahra ^{[1
]}

Harris, James S. ^{[1
]}

Davis, Ronald W. ^{[2
]}

机构：

[1] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[2] Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

来源：

2014 IEEE 27TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS) | 2014年

关键词：

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Previously we presented a novel, label free and real time electrical impedance biosensor, referred to as the nanoneedle biosensor. The nanoneedle is an ultrasensitive and localized device, which has the ability to directly measure biomolecular binding as a function of time. Label-free electronic sensors generally operate in low salt-concentration buffers [1] making them impractical for analyzing complex biological mixtures, which have salt concentrations as high as several hundred millimolar. In this study we have demonstrated detection of a clinically relevant cancer biomarker suspended in high salt buffer (> 100mM) with a detection limit of 2 ng/ml.

引用

页码：1083 / 1086

页数：4

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