In vivo study of endometriosis in mice by photoacoustic microscopy

被引：16

作者：

Ding, Yichen ^{[1
]}

Zhang, Mingzhu ^{[3
]}

Lang, Jinghe ^{[2
]}

Leng, Jinhua ^{[2
]}

Ren, Qiushi ^{[1
]}

Yang, Jie ^{[2
]}

Li, Changhui ^{[1
]}

机构：

[1] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China

[2] Chinese Acad Med Sci, Dept Obstet & Gynecol, Peking Union Med Coll Hosp, Peking Union Med Coll, Beijing 100730, Peoples R China

[3] Chinese Acad Med Sci, Dept Anesthesiol, Canc Inst & Hosp, Beijing 100021, Peoples R China

来源：

JOURNAL OF BIOPHOTONICS | 2015年 / 8卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

endometriosis; optical imaging; photoacoustic microscopy; biomedical optics; OPTOACOUSTIC TOMOGRAPHY; HAPTOGLOBIN; RESOLUTION; TISSUE;

D O I：

10.1002/jbio.201300189

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Endometriosis (EM) impacts the healthcare and the quality of life for women of reproductive age. However, there is no reliable noninvasive diagnosis method for either animal study or clinical use. In this work, a novel imaging method, photoacoustic microscopy (PAM) was employed to study the EM on the mouse model. Our results demonstrated the PAM noninvasively provided the high contrast and 3D imaging of subcutaneously implanted EM tissue in the nude mouse in vivo. The statistical study also indicated PAM had high sensitivity and specificity in the diagnosis of EM in this animal study. In addition, we also discussed the potential clinical application for PAM in the diagnosis of EM.

引用

页码：94 / 101

页数：8

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