Kilogram-Scale Pilot Synthesis of Fingolimod

被引：2
|
作者：
Balaev, A. N. [1 ]
Busel, A. A. [1 ]
Fedorov, V. E. [1 ]
机构：
[1] Farm Sintez Co, 29-134 Vereiskaya St, Moscow 121357, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 06期
关键词：
fingolimod; pilot synthesis; S1P receptor modulator; IMMUNOSUPPRESSIVE AGENT FTY720;
D O I：
10.1007/s11094-017-1636-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A kilogram-scale synthesis of fingolimod drug substance was developed using a 30-L pilot setup. The target product was obtained by a four-step procedure in 99.8% purity and 47% overall yield.
引用
收藏
页码：476 / 479
页数：4
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