Mechanisms and proteins involved in long-distance interactions

被引：52
|
作者：
Maksimenko, Oksana [1 ]
Georgiev, Pavel [2 ]
机构：
[1] Russian Acad Sci, Inst Gene Biol, Lab Gene Express Regulat Dev, Moscow 119334, Russia
[2] Russian Acad Sci, Inst Gene Biol, Dept Control Genet Proc, Moscow 119334, Russia
来源：
FRONTIERS IN GENETICS | 2014年 / 5卷
关键词：
ENHANCER-PROMOTER COMMUNICATION; BETA-GLOBIN LOCUS; DROSOPHILA-BITHORAX COMPLEX; TRANSCRIPTION FACTOR GATA-1; KRUPPEL-LIKE FACTOR; HAIRY-WING PROTEIN; ELEMENT-ASSOCIATED FACTORS; COOPERATIVE DNA-BINDING; PRIMARY ERYTHROID-CELLS; EMBRYONIC STEM-CELLS;
D O I：
10.3389/fgene.2014.00028
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Due to advances in genome-wide technologies, consistent distant interactions within chromosomes of higher eukaryotes have been revealed. In particular, it has been shown that enhancers can specifically and directly interact with promoters by looping out intervening sequences, which can be up to several hundred kilobases long. This review is focused on transcription factors that are supposed to be involved in long-range interactions. Available data are in agreement with the model that several known transcription factors and insulator proteins belong to an abundant but poorly studied class of proteins that are responsible for chromosomal architecture.
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收藏
页数：16
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