Preparation of functionalized aryl magnesium reagents by the addition of magnesium aryl thiolates and amides to arynes

被引：78
|
作者：
Lin, WW [1 ]
Sapountzis, I [1 ]
Knochel, P [1 ]
机构：
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 27期
关键词：
amination; arynes; Grignard reagents; heterocycles; thioethers;
D O I：
10.1002/anie.200500443
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Reactive arynes, which are readily generated by the reaction of ortho-iocloarylsulfonates with iPrMgCl, undergo the smooth addition of various magnesium nucleophiles like magnesium thiolates, selenides, and amides. In all cases the resulting functionalized aryl magnesium species can be trapped by an electrophile leading to highly functionalized aromatic compounds (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4258 / 4261
页数：4
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