Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine

被引:394
作者
Ahmed, Zeeshan [1 ,2 ,3 ,4 ]
Mohamed, Khalid [3 ]
Zeeshan, Saman [5 ]
Dong, Xinqi [1 ,2 ]
机构
[1] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, 112 Paterson St, New Brunswick, NJ 08901 USA
[2] Rutgers Biomed & Hlth Sci, Rutgers Robert Wood Johnson Med Sch, Dept Med, 125 Paterson St, New Brunswick, NJ 08901 USA
[3] Univ Connecticut, Ctr Hlth, Sch Med, Dept Genet & Genome Sci, 263 Farmington Ave, Farmington, CT 06030 USA
[4] Univ Connecticut, Inst Syst Genom, 67 N Eagleville Rd, Storrs, CT 06269 USA
[5] Jackson Lab Genom Med, 10 Discovery Dr, Farmington, CT USA
来源
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2020年
关键词
LINEAR-REGRESSION ANALYSIS; ALGORITHM-NEURAL-NETWORK; HIDDEN MARKOV MODEL; GENETIC ALGORITHM; LOGISTIC-REGRESSION; DECISION-MAKING; DATA-MANAGEMENT; BIG DATA; PROBABILISTIC FUNCTIONS; DISCRIMINANT-ANALYSIS;
D O I
10.1093/database/baaa010
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Precision medicine is one of the recent and powerful developments in medical care, which has the potential to improve the traditional symptom-driven practice of medicine, allowing earlier interventions using advanced diagnostics and tailoring better and economically personalized treatments. Identifying the best pathway to personalized and population medicine involves the ability to analyze comprehensive patient information together with broader aspects to monitor and distinguish between sick and relatively healthy people, which will lead to a better understanding of biological indicators that can signal shifts in health. While the complexities of disease at the individual level have made it difficult to utilize healthcare information in clinical decision-making, some of the existing constraints have been greatly minimized by technological advancements. To implement effective precision medicine with enhanced ability to positively impact patient outcomes and provide real-time decision support, it is important to harness the power of electronic health records by integrating disparate data sources and discovering patient-specific patterns of disease progression. Useful analytic tools, technologies, databases, and approaches are required to augment networking and interoperability of clinical, laboratory and public health systems, as well as addressing ethical and social issues related to the privacy and protection of healthcare data with effective balance. Developing multifunctional machine learning platforms for clinical data extraction, aggregation, management and analysis can support clinicians by efficiently stratifying subjects to understand specific scenarios and optimize decision-making. Implementation of artificial intelligence in healthcare is a compelling vision that has the potential in leading to the significant improvements for achieving the goals of providing real-time, better personalized and population medicine at lower costs. In this study, we focused on analyzing and discussing various published artificial intelligence and machine learning solutions, approaches and perspectives, aiming to advance academic solutions in paving the way for a new data-centric era of discovery in healthcare.
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页数:35
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