Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy

被引：0
|
作者：
Weissenborn, K [1 ]
Berding, G
Köstler, H
机构：
[1] Med Hsch Hannover, Dept Neurol, D-30623 Hannover, Germany
[2] Med Hsch Hannover, Dept Nucl Med, D-30623 Hannover, Germany
[3] Med Hsch Hannover, Dept Neuroradiol, D-30623 Hannover, Germany
来源：
METABOLIC BRAIN DISEASE | 2000年 / 15卷 / 03期
关键词：
D-2 dopamine receptor; dopamine transporter; hepatic encephalopathy;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A patient suffering from liver cirrhosis presented with a bradykinetic-rigid syndrome suspected as Parkinson's disease. A detailed work-up of the case revealed hepatic encephalopathy as the cause of the neurological symptomatology. An alteration of striatal dopamine D-2 receptor binding and dopamine re-uptake sites was demonstrated by I-123-iodobenzamide (IBZM) and I-123-beta -CIT single photon emission computed tomography (SPECT), respectively. It is suggested that the alteration of the dopamine re-uptake in cirrhotics may be the cause of an increased catabolism of dopamine in HE.
引用
收藏
页码：173 / 178
页数：6
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