Spinal cord injury: A model of central neuropathic pain

被引：76
|
作者：
Yezierski, RP
机构：
[1] Univ Florida, Dept Orthodont, Comprehens Ctr Pain Res, Gainesville, FL 32610 USA
[2] Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA
来源：
NEUROSIGNALS | 2005年 / 14卷 / 04期
关键词：
spinal cord injury; central pain; excitotoxicity; plasticity; secondary injury;
D O I：
10.1159/000087657
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The condition of pain after spinal cord injury (SCI) affects the life quality of nearly 70% of individuals with SCI. Clinical studies over the past decade have provided important insights into the complexities of the clinical and psychosocial characteristics of this debilitating consequence of SCI. The use of experimental models developed to study at-level or below-level pain has provided an appreciation for the mechanism(s) responsible for the onset and progression of these conditions. Important to the studies related to SCI pain has been the focus on the molecular, biochemical, anatomical, and functional consequences of SCI that have identified potential therapeutic targets for the design of novel treatment strategies. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码：182 / 193
页数：12
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