Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4+CD25+Foxp3+regulatory T cell expansion

被引：14
|
作者：
Wang, Guo-Ying
Yang, Yang
Li, Hua
Zhang, Jian
Li, Min-Ru
Zhang, Qi [1 ]
Chen, Gui-Hua [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Liver Transplantat Ctr, Guangdong Prov Key Lab Liver Dis Res, Guangzhou 510630, Guangdong, Peoples R China
来源：
HEPATOLOGY RESEARCH | 2012年 / 42卷 / 02期
基金：
中国国家自然科学基金;
关键词：
dendritic cells; immune tolerance; liver transplantation; rapamycin; regulatory T cells; REGULATORY CELLS; CYCLOSPORINE-A; UP-REGULATION; IN-VITRO; TOLERANCE; INDUCTION; RAT; INTERLEUKIN-2; GENERATION; INHIBITION;
D O I：
10.1111/j.1872-034X.2011.00909.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Aim: To determine whether donor immature dendritic cells (imDCs) combined with a short postoperative course of rapamycin (Rapa) has the ability to expand the CD4+CD25+Foxp3+ regulatory T (Treg) cells and prolong liver allograft survival.
引用
收藏
页码：192 / 202
页数：11
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