Highly sensitive determination of benorilate using silver nanoparticles/polyindole/reduced graphene oxide nanocomposite modified electrode

It is known that excessive intake of drugs can cause harmful side effects to the human body. Monitoring of drugs in tablets is important to control levels below allowable limits. Herein a novel electrochemical sensor for sensitive detection of benorilate was developed using silver nanoparticles-polyindole-reduced graphene oxide (AgNPs-PIn-rGO) nanocomposite. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to investigate the electrochemical behavior of benorilate. The AgNPs-PIn-rGO nanocomposite exhibited outstanding electrocatalytic activity toward benorilate. In addition, the effects of scaning rate, pH and accumulation time on the performance of the electrochemical sensor were also studied. Under the optimal condition, the designed sensor showed an appreciable linear response range (0.06 mu M-80 mu M) and a low detection limit (6 nM). Meanwhile, the sensor also displayed excellent selectivity and good storage stability. More importantly, the established method was successfully applied for benorilate determination in pharmaceutical tablets and the result was satisfactory.