The role of alternative splicing in human cancer progression

被引：1

作者：

Ouyang, Jiawei ^{[1
,2
,3
,4
]}

Zhang, Yijie ^{[1
,2
,3
,4
]}

Xiong, Fang ^{[5
]}

Zhang, Shanshan ^{[5
]}

Gong, Zhaojian ^{[6
]}

Yan, Qijia ^{[5
]}

He, Yi ^{[1
,2
,3
]}

Wei, Fang ^{[4
]}

Zhang, Wenling ^{[7
]}

Zhou, Ming ^{[4
]}

Xiang, Bo ^{[4
]}

Wang, Fuyan ^{[4
]}

Li, Xiaoling ^{[4
]}

Li, Yong ^{[8
]}

Li, Guiyuan ^{[4
]}

Zeng, Zhaoyang ^{[1
,2
,3
,4
]}

Guo, Can ^{[4
]}

Xiong, Wei ^{[1
,2
,3
,4
]}

机构：

[1] Cent South Univ, NHC Key Lab Carcinogenesis, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Hunan Key Lab Canc Metab, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China

[3] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Dept Stomatol, Changsha 410013, Hunan, Peoples R China

[6] Cent South Univ, Xiangya Hosp 2, Dept Oral & Maxillofacial Surg, Changsha 410011, Hunan, Peoples R China

[7] Cent South Univ, Xiangya Hosp 3, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Changsha 410013, Hunan, Peoples R China

[8] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Dept Med, Houston, TX 77030 USA

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2021年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Alternative splicing; cancer; splicing factors; isoforms; CircRNA; GROWTH-FACTOR RECEPTOR; RNA-SEQ DATA; MESSENGER-RNA; BREAST-CANCER; CYCLIN D1B; BCL-X; PYRUVATE-KINASE; EXON DEFINITION; CELL-GROWTH; SR PROTEIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In eukaryotes, alternative splicing refers to a process via which a single precursor RNA (pre-RNA) is transcribed into different mature RNAs. Thus, alternative splicing enables the translation of a limited number of coding genes into a large number of proteins with different functions. Although, alternative splicing is common in normal cells, it also plays an important role in cancer development. Alteration in splicing mechanisms and even the participation of non-coding RNAs may cause changes in the splicing patterns of cancer-related genes. This article reviews the latest research on alternative splicing in cancer, with a view to presenting new strategies and guiding future studies related to pathological mechanisms associated with cancer.

引用

页码：4642 / 4667

页数：26

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