For the past month, a 75-year-old woman with polymyalgia rheumatica has received prednisone at a dose of 20 mg daily. The treatment plan is to try to taper the dose to 5 mg daily within 6 months. Given typical durations of treatment, the expectation is that she will continue to receive prednisone for 2 years. She is otherwise healthy and has no personal or family history of fracture. She does not smoke or drink alcohol. Her height is 168 cm, and she weighs 68 kg. Her serum 25-hydroxyvitamin D level is 30 ng per milliliter (74 nmol per liter). Her bone mineral density T score is -1.2 at the femoral neck. What would you advise to prevent glucocorticoid-induced osteoporosis and fracture?
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Univ Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, SwitzerlandUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Rizzoli, R.
Adachi, J. D.
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McMaster Univ, Div Rheumatol, Dept Med, Hamilton, ON, CanadaUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Adachi, J. D.
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Cooper, C.
Dere, W.
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Amgen Inc, Uxbridge, Middx, EnglandUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Dere, W.
Devogelaer, J. P.
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Catholic Univ Louvain, Arthrit Unit UCL5390, B-1200 Brussels, BelgiumUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Devogelaer, J. P.
Diez-Perez, A.
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Univ Autonoma Barcelona, Dept Internal Med, Hosp del Mar, IMIM, E-08193 Barcelona, Spain
Inst Carlos III, RETICEF, Barcelona, SpainUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Diez-Perez, A.
Kanis, J. A.
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Univ Sheffield, Sch Med, Ctr Metab Bone Dis, WHO Collaborating Ctr, Sheffield, S Yorkshire, EnglandUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Kanis, J. A.
Laslop, A.
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AGES PharmMed, Vienna, AustriaUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Laslop, A.
Mitlak, B.
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Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USAUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Mitlak, B.
Papapoulos, S.
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Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, Leiden, NetherlandsUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Papapoulos, S.
Ralston, S.
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Univ Edinburgh, Sch Mol & Clin Med & Arthrit Res, Mol Med Ctr, Western Gen Hosp, Edinburgh, Midlothian, ScotlandUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Ralston, S.
Reiter, S.
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Fed Inst Drugs & Med Devices BfArM, Bonn, GermanyUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Reiter, S.
Werhya, G.
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CHU Nancy, Dept Endocrinol, Vandoeuvre Les Nancy, FranceUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
Werhya, G.
Reginster, J. Y.
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CHU Ctr Ville, Head Bone & Cartilage Metab Unit, Liege, BelgiumUniv Hosp Geneva, Serv Bone Dis, Fac Med, CH-1211 Geneva 14, Switzerland
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Univ Brescia, Dept Internal Med, Brescia, ItalyColl Phys & Surg, Dept Med, 630 W 168th St, New York, NY 10032 USA
Mazziotti, Gherardo
Giustina, Andrea
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Univ Brescia, Dept Internal Med, Brescia, ItalyColl Phys & Surg, Dept Med, 630 W 168th St, New York, NY 10032 USA
Giustina, Andrea
Canalis, Ernesto
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St Francis Hosp & Med Ctr, Dept Res, Hartford, CT 06105 USA
Univ Connecticut, Sch Med, Storrs, CT 06268 USAColl Phys & Surg, Dept Med, 630 W 168th St, New York, NY 10032 USA
Canalis, Ernesto
Bilezikian, John P.
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Coll Phys & Surg, Dept Med, 630 W 168th St, New York, NY 10032 USAColl Phys & Surg, Dept Med, 630 W 168th St, New York, NY 10032 USA