Reactions of nitroxides. Part X: Antifungal activity of selected sulfur and selenium derivatives of 2,2,6,6-tetramethylpiperidine

被引：17
|
作者：
Zakrzewski, Jerzy [1 ]
Krawczyk, Maria [1 ]
机构：
[1] Inst Ind Organ Chem, PL-03236 Warsaw, Poland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期
关键词：
Nitroxyl radicals; Isothiocyanates; Isoselenocyanates; Isocyanides; PROSTATE-CANCER; ISOTHIOCYANATES; SULFORAPHANE; AGENTS; ISOSELENOCYANATES; SELENOUREAS; INHIBITION; INDUCTION; BACTERIAL; GROWTH;
D O I：
10.1016/j.bmcl.2010.10.092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The antifungal activity of nitroxyl radicals-derivatives of 2,2,6,6-tetramethylpiperidine-1-oxyl with reactive substituents 4-isothiocyanato-, 4-isocyano-, and 4-isoselenocyanato- and of N-formyl-, N-thioformyl-, N-selenoformyl-derivatives of 2,2,6,6-tetramethylpiperidine was investigated. Those of the above compounds, which contain a sulfur or selenium atom are the most active against four fungus plant patogens: Botrytis cinerea, Fusarium culmorum, Phytophthora cactorum, Rhizoctonia solani. 4-Isoselenocyanato- 2,2,6,6-tetramethylpiperidine-1-oxyl proved to be the most active compound. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：514 / 516
页数：3
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