The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

Numerous studies have evaluated the association between the 341C/T polymorphism in glutathione S-transferase P1 (GSTP1) and lung cancer risk. However, there are conflicting results from previous studies. To derive a more precise estimation of the association, we conducted this meta-analysis. A comprehensive search was conducted to identify the eligible studies examining the GSTP1 341C/T polymorphism and lung cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The meta-analysis results showed that the GSTP1 341C/T polymorphism was significantly associated with lung cancer risk (TT vs CC: OR = 3.33, 95% CI = 1.49-7.44; CT vs CC: OR = 1.35, 95% CI = 1.10-1.65; dominant model: OR = 1.43, 95% CI = 1.05-1.96; recessive model: OR = 0.31, 95% CI = 0.14-0.70). The results indicate that the GSTP1 341C/T polymorphism may contribute to lung cancer risk. Conclusive evidence on the effects of this variant in lung cancer should be addressed in further studies.