Pharmacogenomics: A primer for the military mental health provider

被引:3
|
作者
Wynn, Gary [1 ]
Jetly, Rakesh [2 ]
Vermetten, Eric [3 ,4 ,5 ]
Rhind, Shawn [6 ]
Willmott, Wayne [7 ]
机构
[1] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA
[2] Dept Natl Def, Canadian Forces Hlth Serv Grp, Ottawa, ON, Canada
[3] Minist Def, Mil Mental Hlth Res, Utrecht, Netherlands
[4] Leiden Univ, Med Ctr, Leiden, Netherlands
[5] ARQ Natl Psychotrauma Ctr, Diemen, Netherlands
[6] Toronto Res Ctr, Def Res & Dev Canada, Toronto, ON, Canada
[7] Dept Natl Def, Canadian Forces Hlth Serv Grp, Directorate Mental Hlth, Ottawa, ON, Canada
关键词
drug interactions; military mental health; NATO; pharmacogenomic testing; pharmacogenomics; pharmacokinetics;
D O I
10.3138/jmvfh.2019-0027
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
While the basics of pharmacokinetics and pharmacodynamics have not changed much in the past two decades, the world of pharmacogenomics has seen much advancement and refinement. These advances have improved the clinical utility and applicability for those caring for individuals with a range of conditions. Indeed, there are now simple clinical tests that can tell a provider potentially useful information about clinical decisions regarding prescribing practices. This article reviews the basics of pharmacokinetics and drug interactions before covering the concepts of pharmacogenomics and pharmacogenomics testing. Further, it discusses the topic of pharmacogenomics testing as it relates to the practice of military mental health providers. It explores several case scenarios to aid in clinical relevance and understanding. This article also addresses the issue of baseline pharmacogenomic testing; A recent Canadian military example and an in-depth table of commercially available pharmacogenomic tests are provided.
引用
收藏
页码:44 / 50
页数:7
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