Studies on agents with vasodilator and beta-blocking activities .4.

被引：0
|
作者：
Seki, T
Nakao, T
Masuda, T
Hasumi, K
Gotanda, K
Ishimori, T
Honma, S
Minami, N
Shibata, K
Yasuda, K
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 11期
关键词：
phenoxypropanolamine; pyridazinone; hypotensive activity; beta-blocking activity; congestive heart failure;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and beta-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.
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页码：2061 / 2069
页数：9
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