Atmospheric Pressure Drift Tube Ion Mobility-Orbitrap Mass Spectrometry: Initial Performance Characterization

被引：34
|
作者：
Keelor, Joel D. [1 ]
Zambrzycki, Stephen [1 ]
Li, Anyin [1 ]
Clowers, Brian H. [2 ]
Fernandez, Facundo M. [1 ]
机构：
[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
[2] Washington State Univ, Dept Chem, Pullman, WA 99164 USA
来源：
ANALYTICAL CHEMISTRY | 2017年 / 89卷 / 21期
基金：
美国国家科学基金会;
关键词：
RESOLVING POWER; SEPARATION; PEPTIDE; MIXTURES; PROTEIN;
D O I：
10.1021/acs.analchem.7b01866
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Atmospheric pressure drift tube ion mobility spectrometry (AP-DTIMS) was coupled with Fourier transform Orbitrap mass spectrometry. The performance capabilities of this versatile new arrangement were demonstrated for different DTIMS ion gating operation modes and Orbitrap mass spectrometer parameters with regard to sensitivity and resolving power. Showcasing the optimized AP-DTIMS-Orbitrap MS system, isobaric peptide and sugar isomers were successfully resolved and the identities of separated species validated by high-energy collision dissociation experiments.
引用
收藏
页码：11301 / 11309
页数：9
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