Absence of circadian salivary cortisol rhythm in women with anorexia nervosa

被引:25
|
作者
dos Santos, Evaldo [1 ]
dos Santos, Jose E. [2 ]
Ribeir, Rosane P. [3 ]
Rosa e Silva, Ana C. J. S. [1 ]
Moreira, Ayrton C. [2 ]
Silva de Sa, Marcos F. [1 ]
机构
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Gynecol & Obstet, BR-14049900 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, BR-14049900 Ribeirao Preto, SP, Brazil
[3] Univ Sao Paulo, Nursing Sch Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
关键词
anorexia nervosa; salivary cortisol; biological rhythm;
D O I
10.1016/j.jpag.2006.10.011
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Study Objective: To compare the cortisol levels and 24 hour salivary cortisol rhythm in patients with anorexia nervosa (AN) and normal controls. Design: Prospective transversal controlled study. Setting: Tertiary-referral University Hospital. Participants: Twenty-five patients aged 15 to 35 years, 13 of them with regular ovulatory cycles, and 12 with diagnosis of AN. Interventions: Salivary and blood collection for cortisol 24-hour rhythm determination. Main Outcome: Salivary cortisol was determined at 9 Am, 5 Pm, and 11 Pm. Seric follicle-stimulating hormone, luteinizing hormone (LH), prolactin, estradiol (E2), progesterone, dehydroepiandrosterone-S (DHEA-S), and cortisol were sampled together with the 9 AM salivary sample. Results: LH, E2, and DHEA-S levels were reduced in patients with AN. A correlation between salivary and serum cortisol levels was observed in the 9 AM sample only in controls (r = 0.67, P = 0.01; AN: r = 0.48, P = 0.12). Cortisol rhythm was present in all control subjects, whereas it was absent in one third of AN patients. The area under the curve for the AN group with preserved rhythm was significantly higher than for the control group (Me = 6811 ng/dl/24h vs 3708 ng/dl/24 h; P = 0.034). Conclusion: Patients with AN have higher salivary cortisol levels when compared to normal women and some of them do not present circadian rhythm.
引用
收藏
页码:13 / 18
页数:6
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