Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8-C29 Fragment

被引：11

作者：

Kawashima, Yuki ^{[1
]}

Toyoshima, Atsushi ^{[1
]}

Fuwa, Haruhiko ^{[1
]}

Sasaki, Makoto ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 09期

基金：

日本学术振兴会;

关键词：

CARIBENOLIDE-I STRUCTURES; SECONDARY ALCOHOLS; OLEFIN METATHESIS; ANTITUMOR MACROLIDE; SELECTIVE OXIDATION; PROPOSED STRUCTURE; DIRECT CONVERSION; ENOL ETHERS; RING; STRATEGY;

D O I：

10.1021/acs.orglett.6b00871

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the C8-C29 fragment of amphidinolide N, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been achieved. The key features of the synthesis involve a convergent union of the C9-C15 and C16-C29 fragments by Steglich esterification and the construction of a pyran unit through a Tebbe methylenation/ring-closing metathesis sequence.

引用

页码：2232 / 2235

页数：4

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