Long-term Experience and Visual Acuity Outcomes in Patients With Peters Anomaly

Purpose:To report the results from a cases series of patients with Peters anomaly and propose management and treatment approaches according to the alterations associated with each case. Methods: The records of 27 patients (32 eyes) clinically diagnosed as having Peters anomaly were analyzed retrospectively. Each patient underwent different treatment modalities (from medical follow-up consultations to penetrating keratoplasty procedures) according to the type of Peters anomaly. Results: Of 32 eyes of 27 patients (74% male and 26% female), 5 patients (18.5%) were bilateral and 22 (81.5%) were unilateral. The average number of years of follow-up consultations was 10.2 years (range: 3.5 to 18 years). The long-term visual acuity (VA) results correlated directly with the type of Peters anomaly. Mean VA for all patients was 1.71 +/- 1.04 logarithm of the minimum angle of resolution (logMAR).The results by group were 0.30 +/- 0.00 logMAR for type I Peters anomaly with only medical monitoring, 0.97 +/- 0.78 logMAR for type I Peters anomaly with only optical iridectomy, 1.22 +/- 0.97 logMAR for type I Peters anomaly with penetrating keratoplasty, 2.41 +/- 0.80 logMAR for type II Peters anomaly without a compromised posterior pole with penetrating keratoplasty, and 2.56 +/- 0.48 logMAR for type II Peters anomaly with a compromised posterior pole with penetrating keratoplasty. Conclusions: The VA result and long-term corneal failure is directly related to the type of Peters anomaly. Patients with type I Peters anomaly who only required medical follow-up consultations had the most favor-able prognosis. Patients in whom penetrating keratoplasty was performed had a poor prognosis.