Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation

被引：158
|
作者：
Xi, Liqiang [2 ]
Arons, Evgeny [1 ]
Navarro, Winnifred [2 ]
Calvo, Katherine R. [3 ]
Stetler-Stevenson, Maryalice [2 ]
Raffeld, Mark [2 ]
Kreitman, Robert J. [1 ]
机构：
[1] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
[2] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA
[3] NIH, Dept Lab Med, Ctr Clin, Bethesda, MD 20892 USA
来源：
BLOOD | 2012年 / 119卷 / 14期
基金：
美国国家卫生研究院;
关键词：
DIAGNOSIS;
D O I：
10.1182/blood-2011-09-379339
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recently, the BRAF V600E mutation was reported in all cases of hairy cell leukemia (HCL) but not in other peripheral B-cell neoplasms. We wished to confirm these results and assess BRAF status in well-characterized cases of HCL associated with poor prognosis, including the immunophenotypically defined HCL variant (HCLv) and HCL expressing the IGHV4-34 immunoglobulin rearrangement. Fifty-three classic HCL (HCLc) and 16 HCLv cases were analyzed for BRAF, including 5 HCLc and 8 HCLv expressing IGHV4-34. BRAF was mutated in 42 (79%) HCLc, but wild-type in 11 (21%) HCLc and 16 (100%) HCLv. All 13 IGHV4-34(+) HCLs were wild-type. IGHV gene usage in the 11 HCLc BRAF wild-type cases included 5 IGHV4-34, 5 other, and 1 unknown. Our results suggest that HCLv and IGHV4-34(+) HCLs have a different pathogenesis than HCLc and that a significant minority of other HCLc are also wild-type for BRAF V600. (Blood. 2012; 119(14): 3330-3332)
引用
收藏
页码：3330 / 3332
页数：3
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