Obesity as the initial manifestation of central nervous system relapse of acute lymphoblastic leukemia: Case report and literature review
被引:8
|
作者:
Zhang, Li-Dan
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机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Zhang, Li-Dan
[1
]
Li, Yan-Hong
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机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Li, Yan-Hong
[1
]
Ke, Zhi-Yong
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机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Ke, Zhi-Yong
[1
]
Huang, Li-Bin
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机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Huang, Li-Bin
[1
]
Luo, Xue-Qun
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机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Luo, Xue-Qun
[1
]
机构:
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Central nervous system leukemia;
childhood;
obesity;
D O I:
10.4103/0973-1482.95200
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
A 6-year-old boy with acute lymphoblastic leukemia in remission experienced hyperphagia, obesity, and emotional disorders. Cytomorphologic examination of cerebral spinal fluid (CSF) and cranial MRI did not help in differentiating between central nervous system leukemia (CNSL) and other CNS diseases including tuberculosis in this boy. Flow cytometric CSF analysis on repeated lumber puncture detected lymphoblasts, while microscopic CSF examination did not definitively show relapse disease. The diagnosis of CNSL was thus made and confirmed by the response to leukemia treatment. Obesity can be the first manifestation of CNSL and the diagnosis can be challenging. A combination of CSF cytomorphology, CSF flow cytometry, and cranial MRI can be useful in the diagnosis of the disease. Two mechanisms of CNSL-related obesity are discussed based on the literature review.
机构:
Rutgers Robert Wood Johnson Med Sch, 3rd Floor, New Brunswick, NJ 08903 USARutgers Robert Wood Johnson Med Sch, 3rd Floor, New Brunswick, NJ 08903 USA
Gorshein, Elan
Kalathil, Sheila
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Hackensack Meridian Hlth Jersey Shore Univ, 1945 Route 33,Ackerman Bldg,3rd Floor, Neptune, NJ 07753 USARutgers Robert Wood Johnson Med Sch, 3rd Floor, New Brunswick, NJ 08903 USA
Kalathil, Sheila
Gharibo, Mecide
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Bayer US LLC, 100 Bayer Blvd, Whippany, NJ 07891 USARutgers Robert Wood Johnson Med Sch, 3rd Floor, New Brunswick, NJ 08903 USA
机构:
Univ Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Sheikh, Irtiza N.
Ragoonanan, Dristhi
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Univ Texas MD Anderson Canc Ctr, Dept Pediat Pediat Stem Cell Transplantat & Cellu, CARTOX Program, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Ragoonanan, Dristhi
Franklin, Anna
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机构:
Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Aurora, CO 80045 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Franklin, Anna
Srinivasan, Chandra
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Childrens Hosp Philadelphia, Cardiac Ctr, Philadelphia, PA 19104 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Srinivasan, Chandra
Zhao, Bhiong
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机构:
Univ Texas Hlth Sci Ctr Houston, Dept Pathol & Lab Med, McGovern Med Sch, Houston, TX 77054 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Zhao, Bhiong
Petropoulos, Demetrios
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Univ Texas MD Anderson Canc Ctr, Dept Pediat Pediat Stem Cell Transplantat & Cellu, CARTOX Program, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Petropoulos, Demetrios
Mahadeo, Kris M.
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机构:
Univ Texas MD Anderson Canc Ctr, Dept Pediat Pediat Stem Cell Transplantat & Cellu, CARTOX Program, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Mahadeo, Kris M.
Tewari, Priti
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机构:
Univ Texas MD Anderson Canc Ctr, Dept Pediat Pediat Stem Cell Transplantat & Cellu, CARTOX Program, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA
Tewari, Priti
Khazal, Sajad J.
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机构:
Univ Texas MD Anderson Canc Ctr, Dept Pediat Pediat Stem Cell Transplantat & Cellu, CARTOX Program, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Div Pediat & Patient Care, Houston, TX 77030 USA