Parenteral nutrition-associated cholestasis in neonates: The role of aluminum

被引：14
|
作者：
Arnold, CJ [1 ]
Miller, GG
Zello, GA
机构：
[1] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK S7M 0Z9, Canada
[2] Univ Saskatchewan, Coll Med, Saskatoon, SK S7M 0Z9, Canada
来源：
NUTRITION REVIEWS | 2003年 / 61卷 / 09期
关键词：
parenteral nutrition; cholestasis; aluminum; contamination;
D O I：
10.1301/nr.2003.sept.306-310
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Parenteral nutrition (PN) is an essential component in the care of premature and ill infants. The incidence of parenteral nutrition-associated cholestasis (PNAC) ranges from 7.4 to 84%. One substance in PN solutions that has been implicated in PNAC is aluminum. Aluminum loading In animals and humans causes hepatic accumulation and damage. The degree of aluminum contamination of PN solutions has decreased over time, but contamination still significantly exceeds levels that are safe for human neonates. Further study into the relationship between aluminum contamination in neonatal PN solutions and the development of PNAC is necessary.
引用
收藏
页码：306 / 310
页数：5
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