Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding

被引：119

作者：

Sunter, Jack ^{[1
]}

Gull, Keith ^{[2
]}

机构：

[1] Oxford Brookes Univ, Dept Biol & Med Sci, Headington Campus, Oxford OX3 0BP, England

[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

OPEN BIOLOGY | 2017年 / 7卷 / 09期

基金：

英国惠康基金;

关键词：

morphology; Leishmania; pathogenicity; parasite; FLAGELLUM ATTACHMENT ZONE; PARASITOPHOROUS VACUOLES; TRYPANOSOMA-BRUCEI; FINE-STRUCTURE; LIFE-CYCLE; CELL-CYCLE; METACYCLIC PROMASTIGOTES; EXTRACELLULAR-MATRIX; PARAFLAGELLAR ROD; LENGTH CONTROL;

D O I：

10.1098/rsob.170165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The evolutionary pressure associated with establishing and maintaining an infection and transmission to vector or host has shaped parasite morphology. However, there is not a 'one size fits all' morphological solution to these different pressures, and parasites exhibit a range of different morphologies, reflecting the diversity of their complex life cycles. In this review, we will focus on the shape and form of Leishmania spp., a group of very successful protozoan parasites that cause a range of diseases from self-healing cutaneous leishmaniasis to visceral leishmaniasis, which is fatal if left untreated.

引用

页数：13