Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier

被引：26

作者：

Zhang, Ruiyi ^{[1
,2
,3
]}

Xue, Mengzhou ^{[3
]}

Yong, Voon Wee ^{[1
,2
]}

机构：

[1] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T3A 4X9, Canada

[2] Univ Calgary, Dept Clin Neurosci, Calgary, AB T3A 4X9, Canada

[3] Zhengzhou Univ, Affiliated Hosp 2, Zhengzhou 450014, Peoples R China

来源：

CELLS | 2021年 / 10卷 / 10期

基金：

中国国家自然科学基金;

关键词：

intracerebral hemorrhage; tissue regeneration; neurogenesis; remyelination; angiogenesis; neuroinflammation; drug therapy; stem cells; rehabilitation; biomaterial; MESENCHYMAL STEM-CELLS; PROMOTES FUNCTIONAL RECOVERY; HEALTH-CARE PROFESSIONALS; RANDOMIZED CONTROLLED-TRIAL; ADULT HUMAN BRAIN; RAT MODEL; MATRIX METALLOPROTEINASES; RECEPTOR; INFLAMMATORY MEDIATORS; NEUROLOGICAL FUNCTIONS;

D O I：

10.3390/cells10102513

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.</p>

引用

页数：22

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