Immunity to seasonal and pandemic influenza A viruses

被引：53
|
作者：
Valkenburg, Sophie A. [2 ]
Rutigliano, John A. [1 ]
Ellebedy, Ali H. [3 ]
Doherty, Peter C. [1 ,2 ]
Thomas, Paul G. [1 ]
Kedzierska, Katherine [2 ]
机构：
[1] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA
[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia
[3] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA
来源：
MICROBES AND INFECTION | 2011年 / 13卷 / 05期
基金：
英国医学研究理事会;
关键词：
Influenza virus; Adaptive immunity; Innate immunity; H1N1; 2009; Antigenic variation; T-CELL RESPONSES; ANTIBODY-RESPONSE; DENDRITIC CELLS; STRUCTURAL BASIS; MATRIX PROTEIN; H1N1; VIRUS; PREEXISTING IMMUNITY; TRANSCRIPTION FACTOR; PROTECTIVE IMMUNITY; EARLY ESTABLISHMENT;
D O I：
10.1016/j.micinf.2011.01.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：489 / 501
页数：13
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