Lateral lithiation in deep eutectic solvents: regioselective functionalization of substituted toluene derivatives

被引：33

作者：

Arnodo, Davide ^{[1
]}

Ghinato, Simone ^{[1
]}

Nejrotti, Stefano ^{[1
]}

Blangetti, Marco ^{[1
]}

Prandi, Cristina ^{[1
]}

机构：

[1] Univ Torino, Dipartimento Chim, Via P Giuria 7, I-10125 Turin, Italy

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 16期

关键词：

AROMATIC TERTIARY AMIDES; ATROPOSELECTIVITY; METALATION; REACTIVITY; BENZAMIDES; CHEMISTRY;

D O I：

10.1039/d0cc00593b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups provide a rapid and high regioselective access to functionalized aromatic derivatives of remarkable synthetic value.

引用

页码：2391 / 2394

页数：4

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