Copper-Catalyzed Oxidative Cyclization of Alkynes with Sulfonylhydrazides Leading to 2-Sulfonated 9H-pyrrolo[1,2-a]indol-9-ones

被引：50

作者：

Zhu, Xin-Yu ^{[1
]}

Li, Ming ^{[1
]}

Han, Ya-Ping ^{[1
]}

Chen, Si ^{[1
]}

Li, Xue-Song ^{[1
]}

Liang, Yong -Min ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 16期

基金：

美国国家科学基金会;

关键词：

TERT-BUTYL HYDROPEROXIDE; SULFONYL HYDRAZIDES; BIOLOGICAL EVALUATION; RADICAL CYCLIZATION; TERMINAL ALKYNES; PHENYL SULFONES; VINYL SULFONES; ACIDS; FUNCTIONALIZATION; HALOSULFONYLATION;

D O I：

10.1021/acs.joc.7b01497

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed oxidative cyclization procedure has been developed for the production of 2-sulfonated 9H-pyrrolo[1,2-a]indol-9-ones via the direct sulfonylation of N-propargyl-substituted indoles with sulfonylhydrazides and tert-butyl hydroperoxide (TBHP). This novel protocol, which tolerates a broad range of functional groups, offers a simple, efficient, and atom-economical route to a series of fluorazones in good yields under mild conditions.

引用

页码：8761 / 8768

页数：8

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