A dynamic microarray device for paired bead-based analysis

被引：51
|
作者：
Teshima, Tetsuhiko [1 ]
Ishihara, Hirotaka [1 ]
Iwai, Kosuke [1 ]
Adachi, Aki [1 ]
Takeuchi, Shoji [1 ,2 ]
机构：
[1] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo, Japan
[2] Kanagawa Acad Sci & Technol, Bio Micro Syst Project, Takatsu Ku, Kawasaki, Kanagawa, Japan
来源：
LAB ON A CHIP | 2010年 / 10卷 / 18期
基金：
日本科学技术振兴机构;
关键词：
MICROFLUIDIC DEVICE; CELL-MEMBRANE; FUSION; SYSTEM; ARRAYS; ELECTROFUSION; ENCAPSULATION; RELEASE; FLOW;
D O I：
10.1039/c004986g
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we have developed a meander-shaped dynamic microfluidic technology that allows us to pair two different types of microbeads in a trapping site. The dynamic microfluidic technology comprises implemented modifications of a conventional dynamic microarray design such as: (i) the combination of a meander-shaped by-pass channel and a trapping channel with a hydrodynamic trapping site and (ii) line-symmetrical formation of the by-pass and trapping channels. Using these modifications, we have successfully trapped different types of sample in one trapping site, and constructed an array of paired beads of different type such as polystyrene beads or hydrogel beads made of agarose, collagen or alginate. We found that this meander-shaped dynamic microfluidic technology is applicable for the observation of interactions between the paired beads such as molecular diffusion.
引用
收藏
页码：2443 / 2448
页数：6
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