What is the role of the bone marrow microenvironment in AML?

被引：6
|
作者：
Mulherkar, Nirupama [1 ]
Scadden, David T. [2 ,3 ]
机构：
[1] NM INK LLC, Chagrin Falls, OH USA
[2] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA
[3] Harvard Univ, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2021年 / 34卷 / 04期
关键词：
Acute myeloid leukemia; AML; Bone marrow microenvironment; Chemotherapy persistence; Hematopoietic stem cells; Leukemic stem cells; mTORC1; Niche; Metabolism; MTOR;
D O I：
10.1016/j.beha.2021.101328
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute myeloid leukemia (AML) continues to be associated with relapse and resistance to chemotherapy. The bone marrow microenvironment in AML has been shown to regulate responsiveness to chemotherapy and to support disease progression. This review summarizes some recent experimental insights into the crucial role of the bone marrow microenvironment in AML and persistence after chemotherapy.
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页数：3
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