Visible-Light-Mediated C-I Difluoroallylation with an α-Aminoalkyl Radical as a Mediator

被引：44
|
作者：
Yue, Fuyang [1 ]
Dong, Jianyang [1 ]
Liu, Yuxiu [1 ]
Wang, Qingmin [1 ]
机构：
[1] Nankai Univ, Coll Chem, Frontiers Sci Ctr New Organ Matter, State Key Lab Elementoorgan Chem,Res Inst Element, Tianjin 300071, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 18期
基金：
中国国家自然科学基金;
关键词：
HALOGEN-ATOM-TRANSFER; BIOLOGICAL-ACTIVITY; UNACTIVATED ALKYL; TRIFLUOROMETHYLATION; DERIVATIVES; GENERATION; CATALYSIS; DESIGN; AGENTS;
D O I：
10.1021/acs.orglett.1c02905
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report a protocol for direct visible-light-mediated C-I difluoroallylation reactions of a-trifluoromethyl arylalkenes with alkyl iodides at room temperature with an alpha-aminoalkyl radical as a mediator. The protocol permits efficient functionalization of various alpha-trifluoromethyl arylalkenes with cyclic and acyclic primary, secondary, and tertiary alkyl iodides and is scalable to the gram level. This mild protocol uses an inexpensive mediator and is suitable for late-stage functionalization of complex natural products and drugs.
引用
收藏
页码：7306 / 7310
页数：5
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