Occulomotor Neural Integrator Dysfunction in Multiple Sclerosis: Insights From Neuroimaging

被引:3
|
作者
Bede, Peter [1 ,2 ,3 ]
Finegan, Eoin [1 ,3 ]
Chipika, Rangariroyashe H. [1 ]
Shing, Stacey Li Hi [1 ]
Lambe, Jeffrey [3 ]
Meaney, James [4 ,5 ]
Redmond, Janice [3 ]
机构
[1] Trinity Coll Dublin, Acad Unit Neurol, Computat Neuroimaging Grp, Dublin, Ireland
[2] Sorbonne Univ, INSERM, CNRS, Lab Imagerie Biomed, Paris, France
[3] St James Hosp, Dept Neurol, Dublin, Ireland
[4] St James Hosp, CAMI, Dublin, Ireland
[5] Trinity Coll Dublin, Sch Med, Dublin, Ireland
来源
FRONTIERS IN NEUROLOGY | 2018年 / 9卷
关键词
multiple sclerosis; nystagmus; brainstem; cerebellum; striatum; thalamus; hippocampus; CLINICALLY ISOLATED SYNDROME; WHITE-MATTER ABNORMALITIES; PLACEBO-CONTROLLED TRIAL; SACCADIC EYE-MOVEMENTS; ACQUIRED NYSTAGMUS; RADIAL DIFFUSIVITIES; PENDULAR NYSTAGMUS; OCULOMOTOR SYSTEM; CORPUS-CALLOSUM; NETWORK MODEL;
D O I
10.3389/fneur.2018.00691
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Magnetic resonance imaging is a key diagnostic and monitoring tool in multiple Sclerosis (MS). While the substrates of motor and neuropsychological symptoms in MS have been extensively investigated, nystagmus-associated imaging signatures are relatively under studied. Accordingly, the objective of this study is the comprehensive characterisation of cortical, subcortical, and brainstem involvement in a cohort of MS patients with gaze-evoked nystagmus. Methods: Patients were recruited from a specialist MS clinic and underwent multimodal neuroimaging including high-resolution structural and diffusion tensor data acquisitions. Morphometric analyses were carried out to evaluate patterns of cortical, subcortical, brainstem, and cerebellar gray matter pathology. Volumetric analyses were also performed to further characterize subcortical gray matter degeneration. White matter integrity was evaluated using axial-, mean-, and radial diffusivity as well as fractional anisotropy. Results : Whole-brain morphometry highlighted considerable brainstem and cerebellar gray matter atrophy, and the tract-wise evaluation of white matter metrics revealed widespread pathology in frontotemporal and parietal regions. Nystagmus-associated gray matter degeneration was identified in medial cerebellar, posterior medullar, central pontine, and superior collicular regions. Volume reductions were identified in the putamen, thalamus and hippocampus. Conclusions: Multiple sclerosis is associated with widespread gray matter pathology which is not limited to cortical regions but involves striatal, thalamic, cerebellar, and hippocampal foci. The imaging signature of gaze-evoked nystagmus in MS confirms the degeneration of key structures of the neural integrator network.
引用
收藏
页数:12
相关论文
共 50 条
  • [21] NEUROIMAGING IN MULTIPLE-SCLEROSIS
    NOSEWORTHY, JH
    PATY, DW
    EBERS, GC
    NEUROLOGIC CLINICS, 1984, 2 (04) : 759 - 777
  • [22] NEUROIMAGING IN MULTIPLE-SCLEROSIS
    FRANCIS, GS
    EVANS, AC
    ARNOLD, DL
    NEUROLOGIC CLINICS, 1995, 13 (01) : 147 - 171
  • [23] Development of Neuroimaging in Multiple Sclerosis
    Thompson, A.
    MULTIPLE SCLEROSIS, 2010, 16 (02): : 255 - 255
  • [24] NEUROIMAGING IN MULTIPLE-SCLEROSIS
    MILLER, DH
    MCDONALD, WI
    CLINICAL NEUROSCIENCE, 1994, 2 (3-4) : 215 - 224
  • [25] Neuroimaging of Multiple Sclerosis Mimics
    Haralur, Yathish
    Mechtler, Laszlo L.
    NEUROLOGIC CLINICS, 2020, 38 (01) : 149 - +
  • [26] "Leaky" and "Unstable" Neural Integrator Can Coexist-Paradox Observed in Multiple Sclerosis
    Gupta, Palak
    Shaikh, Aasef G.
    JOURNAL OF NEURO-OPHTHALMOLOGY, 2020, 40 (02) : 226 - 233
  • [27] The neural bases of prosody: Insights from lesion studies and neuroimaging
    Baum, SR
    Pell, MD
    APHASIOLOGY, 1999, 13 (08) : 581 - 608
  • [28] Neural Mechanisms of Paroxysmal Kinesigenic Dyskinesia: Insights from Neuroimaging
    Liu, Wei
    Xiao, Yan
    Zheng, Ting
    Chen, Guangxiang
    JOURNAL OF NEUROIMAGING, 2021, 31 (02) : 272 - 276
  • [29] Recent advances in the neuroimaging of multiple sclerosis
    Rooney W.D.
    Coyle P.K.
    Current Neurology and Neuroscience Reports, 2005, 5 (3) : 217 - 224
  • [30] Recent advances in neuroimaging of multiple sclerosis
    Rashid, Waqar
    Miller, David H.
    SEMINARS IN NEUROLOGY, 2008, 28 (01) : 46 - 55