Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation

被引：12

作者：

Terutsuki, Daigo ^{[1
]}

Yoroizuka, Hayato ^{[1
]}

Osawa, Shin-ichiro ^{[2
]}

Ogihara, Yuka ^{[1
]}

Abe, Hiroya ^{[1
]}

Nakagawa, Atsuhiro ^{[2
]}

Iwasaki, Masaki ^{[3
]}

Nishizawa, Matsuhiko ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Engn, Dept Finemech, Aoba Ku, 6-6-01 Aramaki Aoba, Sendai, Miyagi 9808579, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Neurosurg, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan

[3] Natl Ctr Neurol & Psychiat NCNP, Natl Ctr Hosp, Dept Neurosurg, 4-1-1 Ogawahigashi Cho, Kodaira, Tokyo 1878551, Japan

来源：

ADVANCED HEALTHCARE MATERIALS | 2022年 / 11卷 / 23期

关键词：

cuff electrodes; hydrogels; MRI compatible implants; self-closing; vagus nerve stimulation; IMPLANTABLE NEUROTECHNOLOGIES; MRI; INTERFACE; THERAPY; SOFT;

D O I：

10.1002/adhm.202201627

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An intrinsically soft organic electrode consisting of poly(3,4-ethylenedioxythiophene)-modified polyurethane (PEDOT-PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self-closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2 mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (approximate to 200 Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT-PU (approximate to 27 mF cm(-2)) ensures a safe stimulation of living tissues without Faradaic reactions. The practical performance of the cuff electrode for VN stimulation is demonstrated by observation of bradycardia induction in a pig.

引用

页数：9

共 22 条

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